FZG Vacuum Tray Dryer for Pharmaceutical Manufacturing: Ibuprofen API Crystals
FZG Vacuum Tray Dryer is evaluated for ibuprofen api crystals in pharmaceutical manufacturing. The defined feed is isolated ibuprofen crystals. Review the material-specific operating requirements below alongside the original equipment specifications.
Ibuprofen API Crystals: Application and Process Requirements
For ibuprofen api crystals, review grade-specific softening behavior and residual-solvent release. Start with isolated ibuprofen crystals, and identify the volatile phase and incoming variability before choosing a cycle.
Feed, Quality and Downstream Interface
| Review item | Ibuprofen API Crystals |
|---|---|
| Defined feed | isolated ibuprofen crystals |
| Material-specific focus | review grade-specific softening behavior and residual-solvent release |
| Product quality checks | residual solvent, moisture, crystal form and particle distribution |
| Downstream handling | contained API packaging before formulation |
Loading and Material Movement
Set layer depth, loading distribution and tray position; inspect the slowest drying locations.
Include residual solvent, moisture, crystal form and particle distribution in the trial record. Define the sampling locations and analytical methods before the test; a result from a different grade, loading pattern or residual liquor cannot establish the operating endpoint for this feed.
Material-Specific Configuration
Vacuum Tray Dryer selection for this feed should be assessed alongside the industrial vacuum dryer process description. Evaluate low-temperature vacuum drying and heat-sensitive material drying with representative ibuprofen api crystals. This pharmaceutical vacuum drying application requires a material-specific sampling and acceptance plan.
After the batch meets the agreed specification, arrange contained API packaging before formulation. Examine the effect of discharge, temporary holding and packaging exposure on the measured product condition. Establish the usable batch and cycle for this material; the original model parameters below remain the equipment reference, not a throughput promise for every formulation.
View the FZG Vacuum Tray Dryer range and original equipment specifications
Technical References for This Application
Agree material-specific sampling and acceptance criteria for the process. FDA process-validation guidance.
Review the quality and documentation requirements appropriate to the pharmaceutical duty. FDA Q7A manufacturing guidance.
Define product-contact surfaces, cleaning access and changeover requirements. FDA equipment and cleaning guidance.
Apply the relevant residual-solvent specification to the actual formulation; this is separate from water content. FDA ICH Q3C residual-solvent guidance.
Use the actual powder test data when defining dust collection and handling. HSE combustible-dust handling guidance.
Equipment Reference Parameters
These are the FZG Vacuum Tray Dryer model specifications. The operating duty for ibuprofen api crystals must be established from the feed and the finished-product requirements above.
| Item | YZG-600 | YZG-1000 | YZG-1400 | FZG-8 | FZG-15 | FZG-20 | FZG-30 | FZG-45 |
|---|---|---|---|---|---|---|---|---|
| Internal Chamber Dimensions (mm) | Φ600×976 | Φ1000×1527 | Φ1400×2054 | 1140×890×1400 | 1500×1220×1400 | 1500×1800×1400 | 3200×1220×1400 | 3200×1220×1700 |
| Overall Dimensions (mm) | 1150×810×1020 | 1740×1226×1385 | 2386×1657×1800 | 1580×1203×1924 | 2060×1513×1924 | 2060×1883×1924 | 3760×1513×1924 | 3760×1513×2224 |
| Shelf Layers | 4 | 6 | 8 | 8 | 8 | 8 | 8 | 12 |
| Layer Spacing (mm) | 81 | 98 | 102 | 122 | 122 | 122 | 122 | 102 |
| Tray Dimensions (mm) | 310×600×45 | 640×460×45 | 640×460×45 | 640×460×45 | 640×460×45 | 640×460×45 | 640×460×45 | 640×460×45 |
| Number of Trays | 4 | 12 | 32 | 16 | 32 | 48 | 64 | 96 |
| Capacity (kg) | 5 | 30 | 60–80 | 30–40 | 60–80 | 100–120 | 130–150 | 200–240 |
| Allowable Heating-Pipe Pressure (MPa) | ≤0.784 | ≤0.784 | ≤0.784 | ≤0.784 | ≤0.784 | ≤0.784 | ≤0.784 | ≤0.784 |
| Operating Temperature (°C) | 35–150 | 35–150 | 35–150 | 35–150 | 35–150 | 35–150 | 35–150 | 35–150 |
| No-Load Chamber Vacuum (MPa) | −0.09 to −0.096 | −0.09 to −0.096 | −0.09 to −0.096 | −0.09 to −0.096 | −0.09 to −0.096 | −0.09 to −0.096 | −0.09 to −0.096 | −0.09 to −0.096 |
| Vacuum-Pump Model and Power | SK-1.5, 3 kW | SK-3, 5.5 kW | SK-6, 11 kW | SK-3, 5.5 kW | SK-6, 11 kW | SK-6, 11 kW | SK-12, 18.5 kW | SK-12, 18.5 kW |
| Weight (kg) | 400 | 900 | 1400 | 1400 | 2300 | 2800 | 3500 | 4800 |
| Selection Item | Information Required |
| Material | Composition, consistency and bulk density |
| Batch | Required loading quantity and production schedule |
| Moisture | Initial moisture and target final moisture |
| Temperature | Product temperature limit and heating utilities |
| Vacuum | Process pressure and expected vapor load |
| Construction | Contact materials, seals and cleaning requirements |
| Installation | Space, access and process connections |
Discuss Ibuprofen API Crystals Drying
Send QUANPIN the incoming ibuprofen api crystals specification, sample information and the required final product condition for an equipment review.
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